Current version of Eduke32 has a music glitch.
Which music will fail to start randomly (sadly cure for that is restart Eduke32)

Sounds wont be effected thought.

But check for newer release of Eduke incase a version with the "music bug" is fixed.

Also about a popup message occurs outside my Duke folder.

If you see a message saying;
"unsupported OpenGL driver"

pops up click ok. It doesn't seem to effect the game thought.
So is nothing serious.